This week some of my students had a brilliant idea to organise a drinking Marathon Monday after their final exam. It wasn’t meant that seriously, but pretty soon the idea caught on and they discovered the power of social media when over 4000 other students signed up for their Binge drinking fest.

So I ended up explaining to national tv that our institute didn’t support such a thing, but that we couldn’t forbid it as they are adults. Mails with apologies followed.

But why is this such a stupid idea? Well, new research shows that a single episode of binge drinking can have significant negative health effects resulting in bacteria leaking from the gut, leading to increased levels of endotoxins in the blood, clinical scientists have found. Greater gut permeability and increased endotoxin levels have been linked to many of the health issues related to chronic drinking, including alcoholic liver disease.

Abstract from the research (Free access):

Binge drinking, the most common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its biological consequences are poorly defined. Previous studies demonstrated that chronic alcohol use results in increased gut permeability and increased serum endotoxin levels that contribute to many of the biological effects of chronic alcohol, including alcoholic liver disease. In this study, we evaluated the effects of acute binge drinking in healthy adults on serum endotoxin levels. We found that acute alcohol binge resulted in a rapid increase in serum endotoxin and 16S rDNA, a marker of bacterial translocation from the gut. Compared to men, women had higher blood alcohol and circulating endotoxin levels. In addition, alcohol binge caused a prolonged increase in acute phase protein levels in the systemic circulation. The biological significance of the in vivo endotoxin elevation was underscored by increased levels of inflammatory cytokines, TNFα and IL-6, and chemokine, MCP-1, measured in total blood after in vitro lipopolysaccharide stimulation. Our findings indicate that even a single alcohol binge results in increased serum endotoxin levels likely due to translocation of gut bacterial products and disturbs innate immune responses that can contribute to the deleterious effects of binge drinking.