Early life stress can leave lasting impacts on the brain

New research confirms insights we brought here earlier on, stress early in life can have lasting impacts on the brain and that eg poverty molds the brain. So for children, stress can go a long way. A little bit of stress is not necessarily a bad thing as it provides a platform for learning, adapting and coping. But a lot of it — chronic, toxic stress like poverty, neglect and physical abuse — can have lasting negative impacts. A team of researchers at the University of Wisconsin-Madison found that these kinds of stressors, experienced in early life, might be changing the parts of developing children’s brains responsible for learning, memory and the processing of stress and emotion. Different forms of early life stress, such as child maltreatment or poverty, impacted the size of two important brain regions: the hippocampus and amygdala. Children who experienced such stress had small amygdalae and hippocampai, which was related to behavioral problems in these same individuals.

From the press release:

The study, published in the journal Biological Psychiatry, could be important for public policy leaders, economists and epidemiologists, among others, says study lead author and recent UW Ph.D. graduate Jamie Hanson.

“We haven’t really understood why things that happen when you’re 2, 3, 4 years old stay with you and have a lasting impact,” says Seth Pollak, co-leader of the study and UW-Madison professor of psychology.

Yet, early life stress has been tied before to depression, anxiety, heart disease, cancer, and a lack of educational and employment success, says Pollak, who is also director of the UW Waisman Center’s Child Emotion Research Laboratory.

“Given how costly these early stressful experiences are for society … unless we understand what part of the brain is affected, we won’t be able to tailor something to do about it,” he says.

For the study, the team recruited 128 children around age 12 who had experienced either physical abuse, neglect early in life or came from low socioeconomic status households.

Researchers conducted extensive interviews with the children and their caregivers, documenting behavioral problems and their cumulative life stress. They also took images of the children’s brains, focusing on the hippocampus and amygdala, which are involved in emotion and stress processing. They were compared to similar children from middle-class households who had not been maltreated.

Hanson and the team outlined by hand each child’s hippocampus and amygdala and calculated their volumes. Both structures are very small, especially in children (the word amygdala is Greek for almond, reflecting its size and shape in adults), and Hanson and Pollak say the automated software measurements from other studies may be prone to error.

Indeed, their hand measurements found that children who experienced any of the three types of early life stress had smaller amygdalas than children who had not. Children from low socioeconomic status households and children who had been physically abused also had smaller hippocampal volumes. Putting the same images through automated software showed no effects.

Behavioral problems and increased cumulative life stress were also linked to smaller hippocampus and amygdala volumes.

Why early life stress may lead to smaller brain structures is unknown, says Hanson, now a postdoctoral researcher at Duke University’s Laboratory for NeuroGenetics, but a smaller hippocampus is a demonstrated risk factor for negative outcomes. The amygdala is much less understood and future work will focus on the significance of these volume changes.

“For me, it’s an important reminder that as a society we need to attend to the types of experiences children are having,” Pollak says. “We are shaping the people these individuals will become.”

But the findings, Hanson and Pollak say, are just markers for neurobiological change; a display of the robustness of the human brain, the flexibility of human biology. They aren’t a crystal ball to be used to see the future.

“Just because it’s in the brain doesn’t mean it’s destiny,” says Hanson.

Abstract of the research:

Background
Early life stress (ELS) can compromise development, with higher amounts of adversity linked to behavior problems. To understand this linkage, a growing body of research has examined two brain regions involved with socio-emotional functioning- the amygdala and hippocampus. Yet empirical studies have reported increases, decreases, and also no differences within human and non-human animal samples exposed to different forms of ELS. Divergence in findings may stem from methodological factors and/or non-linear effects of ELS.

Methods
We completed rigorous hand-tracing of the amygdala and hippocampus in three samples of children who suffered different forms of ELS (i.e., physical abuse, early neglect, or low SES). In addition, interview-based measures of cumulative life stress were also collected with children and their parents or guardians. These same measures were also collected in a fourth sample of comparison children who had not suffered any of these forms of ELS.

Results
Smaller amygdala volumes were found for children exposed to these different forms of ELS. Smaller hippocampal volumes were also noted for children who suffered physical abuse or from low SES-households. Smaller amygdala and hippocampal volumes were also associated with greater cumulative stress exposure and also behavior problems. Hippocampal volumes partially mediated the relationship between ELS and greater behavior problems.

Conclusions
This study suggests ELS may shape the development of brain areas involved with emotion processing and regulation in similar ways. Differences in the amygdala and hippocampus may be a shared diathesis for later negative outcomes related to ELS.

 

5 thoughts on “Early life stress can leave lasting impacts on the brain

  1. […] Eerder onderzoek deed het al vermoeden, maar een nieuw artikel in Nature bevestigt: kinderen die opgroeien in armoede hebben gemiddeld een kleiner brein dan kinderen die in rijkere omstandigheden opgroeien. Hiervoor bekeken de onderzoekers 1099 kinderen en jongeren tussen 2 en 20 jaar, waarbij gecontroleerd werd voor ethnische verschillen. Het verschil in gemiddelde breinoppervlakte tussen de armste en rijkste groep bedroeg 6%. […]

  2. […] This study should come with a warning ‘don’t try this at home’, and no, tiger moms, do sit down. This new study indicates that early experiences of environmental harshness, in combination with a child’s temperament, can influence later problem-solving abilities. But do know that other studies also show negative effects, no really. […]

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