A webtool to check the MaTCH Meta-Analysis of Twin Correlations and Heritability

There is a new meta-analysis of twin studies, just published in Nature by Polderman et al. and it’s huge. The researchers compared 50 years of twin studies to examine to what extent a trait is heritable:

Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial. We report a meta-analysis of twin correlations and reported variance components for 17,804 traits from 2,748 publications including 14,558,903 partly dependent twin pairs, virtually all published twin studies of complex traits. Estimates of heritability cluster strongly within functional domains, and across all traits the reported heritability is 49%. For a majority (69%) of traits, the observed twin correlations are consistent with a simple and parsimonious model where twin resemblance is solely due to additive genetic variation. The data are inconsistent with substantial influences from shared environment or non-additive genetic variation. This study provides the most comprehensive analysis of the causes of individual differences in human traits thus far and will guide future gene-mapping efforts. All the results can be visualized using the MaTCH webtool.

And indeed, added to the meta-study in Nature, they added a free webtool to provide

…a resource for the heritability of all human traits that have been investigated with the classical twin design. The traits have been classified into 28 broad trait domains, as well as according to the standard classification schemes of the International Classification of Functioning, Disability and Health (ICF) or the International Classification of Diseases and Related Health Problems (ICD-10). Currently the database includes information from 2748 papers, published between 1958 and 2012, reporting on 17804 traits on a total of 14,558,903 twin pairs.

Check the webtool here: http://match.ctglab.nl/#/home

Reference to the original paper: Polderman TJC, Benyamin B, de Leeuw CA, Sullivan PF, van Bochoven A, Visscher PM, Posthuma D. Meta-Analysis of the Heritability of Human Traits based on Fifty Years of Twin Studies. Nature Genetics, doi:10.1038/ng.3285, published online May 18, 2015



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